Cross Talk on SARS-CoV-2 and Human Immunity

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes disease 2019 (COVID-19) is now leading cause of death globally. This review elaborated human immune response to SARSCoV-2 and its evasion mechanisms as well factors determine case fatality rate effective immunity using articles selected from PubMed, Medline, Google Scholar Science Direct provided an in-depth knowledge immunopathogenesis SARS-CoV-2. Findings forty eligible reviewed revealed host-viral interaction SARS-CoV-2 involves recognition SARS-CoV-2, recruitment adaptor proteins antigen presentation which activates both innate adaptive involved in inhibition viral replication (interferons), destruction virus-infected cells (natural killer CD8 cells) clearance. However, subverts multiple strategies such production double membrane vesicles, repression proteins, interferons presentation. Accumulating shreds evidence have shown several age, sex, comorbidities, obesity, lifestyle affect responsiveness Hence, better interactions with host determining prevalence severity fundamental management development biocompatible prophylactic therapeutic options.